The 4 Best Cholesterol Lowering Supplement Reviews And Results [2021]

What are Cholesterol Lowering Supplements?

We have all heard about cholesterol. You may just have a vague idea about this substance but it is a pretty well-known fact that excess of it can create serious health issues. How exactly?

Cholesterol is basically a wax-like or fat-like substance that is found in your blood. This substance can be produced in the body or even consumed through foods such as animal products. While many people assume that cholesterol is harmful, it is not. In fact, the human body uses cholesterol to build healthy cells. It is when cholesterol is present in high levels that you face the risk of heart disease and the blockage of blood vessels courtesy of fatty deposits.

It is worth noting that there are 2 types of cholesterol- High-density Lipoprotein Cholesterol (HDL: good cholesterol) and Low-Density Lipoprotein Cholesterol (LDL: bad cholesterol). Naturally, one should aim to lower the levels of bad cholesterol in the body and create a healthy balance between these two types of cholesterol.

Scores of people from around the world face health issues with regard to high levels of bad cholesterol in their bodies. As such, cholesterol-lowering supplements have become one of the latest trends in the healthcare industry. While adopting a healthier diet can surely lower the cholesterol levels in your body, these supplements achieve the needful in a quicker fashion. But which are the best supplements to lower cholesterol?

In order to help you with this, our review team has compiled the best supplements to lower cholesterol in a natural and healthy manner. This article presents the most comprehensive and updated list of the best cholesterol-lowering supplements brands which are sure to help you embrace good health sooner than ever.

Here Are The 4 Best Cholesterol Lowering Supplements

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Genius Heart
Red Yeast Rice

1. CholesLo

World’s best Natural Cholesterol Lowering Supplement

Buy this product from the official website at the lowest price

The CholesLo is the best cholesterol lowering supplement in our list. For starters, it is the only doctor-formulated “all-in-one” natural remedy for lowering the levels of LDL cholesterol. The doctor in question is Dr Sam Robbins, a Registered Orthomolecular Health Practitioner (ROHP), who holds a doctorate in Molecular and Medical Pharmacology, and the product is a brainchild of HFL Solutions, a premier online company that sells health supplements. This just goes on to show the level of expertise behind this remarkable product.

CholesLo is a supremely effective and natural product that comes with amazing functionality, and it is of no wonder that it has garnered rave reviews and acclaim among doctors, medical professionals and online customers alike. It is crafted with the power of medical science and boasts of remarkable cholesterol lowering characteristics, which consequently lower the risk of heart disease. As such, the use of this product contributes towards a healthier heart.

It also goes on to keep your liver clean, lowers the levels of fatty triglycerides in your bloodstream and promotes a proper balance of your hormones. In short, CholesLo enhances the overall health of your body.


Ingredients can make or break a product. And quite often, the ingredients alone don’t suffice in offering a good functionality of the product. As such, the CholesLo cholesterol lowering supplement host 5 potent blends which correspond to 5 different systems, each of which contributes towards the overall functionality of the supplement. Let us check out the systems and the ingredients comprising each of them:

1. Lipid optimizing system:

This system contains of ingredients which effectively lower your cholesterol and lipid levels. These are:

  • Garlic: This immensely popular ingredient has been used since ages to promote good blood circulation through the body and lower the levels of LDL cholesterol.
  • Artichoke leaf extract: It helps in lowering the effects of cholesterol and blood sugar, and also promotes the secretion of bile. This consequently helps your body in the absorption of nutrients and the digestion of fats in the body.
  • Red Yeast Rice: One of the most effective cholesterol lowering agents, it contains statin: a highly potent component to combat high cholesterol levels. As such, the presence of red yeast rice can lower the levels of total cholesterol and bad cholesterol (LCL). In addition, it also increases the levels of good cholesterol (HDL).
  • Phytosterols Complex: It helps in lowering the levels of bad cholesterol.
  • Pantesin d-Pantethine: Lowers the levels of LDL and triglycerides. It also increases the levels of HDL.
  • Ubiquinone: This component is produced naturally in the body and it helps to create energy in the cells. It helps to keep the levels of blood sugar down and also contributes towards a healthy heart.
  • Guggul Gum: It helps in the production of bile and lowers the levels of bad cholesterol.

Read full review of Choleslo

2. Liver cleansing system

As it is evident from the name, this system consists of ingredients that promote healthy functioning of the liver.

  • Milk Thistle: Theoretically helps in the proper maintenance of the liver.
  • N-Acetyl L-Cysteine (NAC): This amino acid lowers the levels of cholesterol and improves the functioning of the liver.

3. Inflammation reducing system:

This system consists of strong ingredients that help to keep potential infections at bay.

  • Turmeric: Containing the active component curcumin, this ingredient decreases the levels of cholesterol and protects against inflammations.
  • Mixed Tocotrienols: Theoretically supposed to decrease the levels of cholesterol.

4. Blood sugar and insulin reducing system:

  • R+ Alpha Lipoic Acid: It controls the blood sugar levels.

5. Homocysteine reducing system:

High levels of homocysteine (an amino acid) result in an increased risk of heart disease. The ingredients in this system include Vitamins B6, B12 (the best vitamins to lower cholesterol) and Folate.

How does the CholesLo work?

CholesLo works by integrating its 5 systems: lipid optimizing system, liver cleansing system, inflammation reducing system, blood sugar and insulin reducing system and homocysteine reducing system by virtue of the functional characteristics of its ingredients. The primary working of the supplement not only lowers the levels of the LDL (bad) cholesterol, but also increases the levels of the HDL (good) cholesterol, thereby creating a proper balance between the two types of cholesterol. All the ingredients are blended into the 5 systems with the most optimal quantities to ensure maximum effectiveness.


Directions for usage

You should ideally take 2 capsules, each twice a day along with your meals for around 2 months.

If you are not satisfied with the results in this time, you can increase the dosage to 2 capsules, each thrice a day.

You need not take the capsules in the weekend (Saturdays and Sundays).

For those who have been taking prescription medicine, it is advised to consult your doctor in person before you take the CholesLo supplements.

Pregnant and breastfeeding women and people under the age of 18 should not take this product at all.

Side effects

The CholesLo cholesterol lowering supplement consists of safe and powerful ingredients that are blended in the right amounts in the form of systems. These are natural and cause no side effects whatsoever. It is important to stick to the recommended dosage at all times.

There have been minor reports of stomach upset and joint pain. So we would recommend you to consult a doctor before you take any supplements that lower cholesterol.

Why should you buy this product?

Go to any healthcare forum and post this query, what is the best natural cholesterol lowering supplement? Surely they will address you CholesLo. It is the best cholesterol lowering supplement that works. It boasts of a unique and amazingly effective functionality with its set of ingredients that make it a class apart from the rest of the supplements available out there. There are many reasons to buy this product. These include:

  • The only doctor formulated cholesterol lowering supplement available.
  • All the individual ingredients  lower cholesterol levels.
  • The company behind CholesLo, HFL Solutions, has conducted several scientific trials that prove the functionality of their product.
  • It has no side effects.
  • The supplement helps you to achieve an optimal HDL.LDL ratio.
  • It also contributes towards the cleansing and maintenance of the liver.
  • The use of this supplement renders a proper hormonal balance in the body.
  • It lowers the risk of heart disease and contributes towards the overall health of the body.
  • The product comes with an astounding refund policy.

Purchase, Prices and Offers

A single bottle of CholesLo contains 80 capsules and it is to be used as a 2 month supply.

  • 1 bottle of CholesLo comes at a price of $49.97, wherein you save $20.00
  • 1 bottle of CholesLo with the “Áuto-Ship” Club comes at a price of $39.97, wherein you save $30.00
  • 2 bottles of CholesLo comes at a price of $99.97 and you get 1 bottle for free. You save $110.00.
  • 4 bottles of CholesLo comes at a price of $199.97 and you get 3 bottles for free. You save $240.00.

Shipping and handling charges are applicable.

Buy the CholesLo here.

Return and Refund

This is perhaps the most interesting part of CholesLo.

What’s the best refund policy you can expect out of a product?

A full refund, right?

CholesLo offers you an unimaginable 200% refund policy! That’s how much faith the manufacturers of CholesLo have in their product.

Choleslo Full review here

2. Nature Made CholestOff

Nature Made CholestOff

The CholestOff marginally edges out this amazing product. The Nature Made CholestOff is one of the best cholesterol lowering supplements available out there. Needless to say, this cholesterol lowering supplement always delivers.

The Nature Made CholestOff is equipped with the ever coveted Reductol, a powerful proprietary blend known to ruthlessly lower the levels of LDL while also working on reducing the risk of heart disease. As per Nature Made (a reputed California based manufacturer of health supplements), Reductol essentially “works as a catalyst that blocks the absorption of cholesterol in the gut.”

A single serving of this cholesterol lowering supplement contains 0.9g of plant sterols and stanols which are an outcome of extensive research by Nature Made. With all these amazing features of CholestOff, it is pretty obvious that it is almost a compulsory part of your cholesterol lowering regimen.


The Nature Made Cholestoff keeps it simple. It has a huge dosage of 900mg of plant sterols and  pine tree based stanols. This is the one and only active ingredient present in this supplement. The other ingredients in this product include ones which don’t contribute towards the cholesterol lowering supplement. Let us check out some of these ingredients and the purpose that they serve:

  • Hydroxypropyl Methylcellulose: Capsules use this as a coating agent.
  • Silicon dioxide: This is an anticaking agent which effectively absorbs moisture.
  • Croscarmellose sodium and Polysorbate 80: They act as emulsifying agents.
  • Magnesium stearate: Common in weight loss pills, this ingredient prevents the individual ingredients comprising the capsules from sticking to each other and the machine manufacturing the capsules.
  • Triethyl citrate: Capsules use this ingredient to maintain the stability of foams and also as a coating agent.

How does the Nature Made CholestOff work?

CholestOff only active ingredient is its potent blend of plant sterols and stanols. This composition is scientifically proven to lower the levels of LDL and creates a proper balance of the HDL.LDL ratio. This also contributes towards the general wellness of the body.

It is worth noting that plant sterols are basically the plant version of cholesterol that you generally get from animal products. But contrary to the latter, plant sterols actually help in lowering the levels of cholesterol.

Directions for usage

It is recommended to take 2 capsules of CholestOff, 2 times a day around 30 minutes before your meals.

Side effects

This supplement has no side effects whatsoever. However, this supplement cannot be used by people below the age of 18 years, pregnant or breastfeeding women, people with other medical conditions and those who possibly have an allergy to pine tree.

Why should you buy this product?

The Nature Made CholestOff is the 2nd best cholesterol lowering supplement on this list. It comes with one of the best functionalities you can get out of a cholesterol lowering supplement with its potent plat sterols and stanols. As such, it is one of the best products to get for you. Here’s why:

  • Plant sterols and stanols make up the 100% natural formulation of CholestOff.
  • The supplement contains Reductol, one of the best known substances known to reduce bad cholesterol.
  • It is safe to use and has no side effects.
  • It contains no artificial colors, harmful additives or preservatives.
  • CholestOff contributes towards the overall cardiovascular health of your body and your overall health in general.
  • It is very affordable and cost effective.

Purchase, Prices and Offers

A single bottle of Nature Made CholestOff contains 60 or 120 capsules depending on the size of the package you purchase.

1 bottle of Nature Made CholestOff (15 days supply) comes at a price of $10.35.

Buy the Nature Made CholestOff here.

3. Genius Heart and Cardiovascular

Genius Heart and Cardiovascular

As you might have guessed from the name of this supplement, it achieves more than just lowering your cholesterol levels. It lowers your blood pressure effectively, reduces the risk of heart disease, promotes the supply of fresh oxygenated blood throughout your body, enhances the endurance of your cardiovascular system by supplying more oxygen and last but not the least, it boosts your cognitive functions. This supplement literally puts a check in all departments. As such, this amazing supplement rounds up as an ideal product for people aiming for good overall health and wellness.


The Genius Heart and Cardiovascular serves its functionality by virtue of its 4 potent ingredients which are present in the most optimal amounts.

  • Pantesin Pantethine: This is one of the most supreme ingredients to support healthy lipid levels and contribute towards the overall cardiovascular health.
  • MenaQ7 Vitamin K2: It paves the way for a healthy heart and also prevents the clotting of blood.
  • Grape Seed Extract: It supports cognitive function, lowers blood pressure and maintains a healthy heart.
  • MicoActive CoQ10: Improves the health of your heart, reduce stress and support the tissues.

How does the Genius Heart and Cardiovascular work?

The ingredient Pantesin Panthethine is primarily responsible for the functionality of this cholesterol lowering supplement.

This ingredient is super effective in balancing the levels of the HDL and LDL in the body while also supporting the effective functioning of the heart. While the lowering of the levels of the bad cholesterol is achieved by Pantesin, the other ingredients serve other important functions such as the better flow of blood and oxygen through the body and maintaining the health of the heart. In short, all the ingredients comprising this supplement work together to better your health in a natural and holistic way.

Directions for usage

You should ideally take 1 capsule, twice a day along with your meals.

Side effects

The Genius Heart and Cardiovascular is an all-rounder. It contributes towards an overall well-being of the body and comes with no side effects associated with it. It excels in its functionality with a limited yet powerful set of ingredients that serve its purpose in a natural way. This is one of the safest cholesterol lowering supplements to take.

Why should you buy this product?

The Genius Heart and Cardiovascular is indeed a genius choice. As mentioned numerous times already, it gives an all-round performance with its remarkable set of functionalities that make you healthier than ever before. Let us see what makes this one of the best supplements to use.

  • This supplement provides a versatile set of functionalities that contribute towards the overall health of the body.
  • The ingredients are 100% natural.
  • It very effectively boosts your cognitive functions.
  • The product is safe to use and has no side effects.
  • The supplement aptly supports good cardiovascular health.
  • It helps in supplying fresh blood and oxygen throughout the body.

Purchase, Prices and Offers

A single bottle of Genius Heart and Cardiovascular contains 60 capsules.

1 bottle of Genius Heart and Cardiovascular (1 month supply) comes at a price of $44.99.

Buy the Genius Heart and Cardiovascular here.

4. HPF Cholestene Red Yeast Rice

The biggest USP of this powerful cholesterol lowering supplement is apparent from its namesake. Composed of red yeast rice like a one man army, this is the primary and the only ingredient compiled in the product. Red yeast rice has been scientifically proven to effectively lower the levels of the LDL cholesterol within just a matter of a month. In addition, it also serves other useful purposes such as improving metabolic syndromes, reducing inflammations, promote good heart health and also help in combating obesity.

You would be glad to note that HPF is a premier brand in manufacturing several healthcare supplements and products in general, and has always been widely acclaimed for their high quality products. In fact, cholestoff vs red yeast rice is a very popular debate, and that shows how top grade the supplements in this list are. As such, you can bet on the quality and efficiency of their cholesterol lowering supplement.


The PF Cholestene has red yeast rice as the sole ingredient in a generous 1200mg dosage to achieve its functionality. This single ingredient is more than enough to serve all the purposes expected from this product.

How does the HPF Cholestene Red Yeast Rice work?

While this supplement may only contain a single ingredient, it is worth noting that this single ingredient, red yeast rice, is sufficient as it boasts of many amazing benefits. It achieves the prime functionality of lowering the levels of the LDL cholesterol solely by the virtue of the red yeast rice. It is worth noting that the working of red yeast rice tends to surpass that of many natural ingredients. The credit for this goes to the content of Monacolin K, which effectively lowers the cholesterol levels and reduces the risk of heart disease.

But that’s not all.

Red yeast rice lowers leptin levels translating to an even further decrease in the levels of cholesterol. This helps in managing obesity.

Last but not the least; red yeast rice aids people with high cholesterol levels by improving the flexibility of blood vessels and lowering the stiffness of blood vessels.

Who would have thought of so many benefits from a single ingredient!

Directions for usage

You should ideally take 4 capsules per day, 2 each with the meals in morning and the afternoon.

Side effects

Red yeast rice is made by growing yeast (Monascus purpureus) on white rice. While red yeast rice is proven to reduce the levels of bad cholesterol and contribute towards the overall health of your body, there are a few minor side effects associated with it. These include headaches, dizziness or gas. That said, these side effects are rare and will mostly never occur unless you take the capsules more than the recommended dosage.

Why should you buy this product?

The HPF Cholestene Red Yeast Rice is perhaps the most impressive and interesting cholesterol lowering supplement in our list. We are still in awe of the many benefits one can get from a single ingredient and we can vouch that you would also be in awe of this supplement as a whole.

  • This supplement packs a single in red yeast rice that serves as a super ingredient that fulfills several purposes.
  • It helps in managing obesity.
  • The functionality of the red yeast rice is often more potent than most natural ingredients used in cholesterol lowering supplements.
  • It promotes the healthy working and maintenance of the heart.
  • It has little to no side effects.

Purchase, Prices and Offers

A single bottle of HPF Cholestene Red Yeast Rice contains 120 capsules.

1 bottle of HPF Cholestene Red Yeast Rice (1 month supply) comes at a price of $12.68, wherein you save 62% from the original price of $32.99.

Buy the HPF Cholestene Red Yeast Rice here.

Scientific Research

(Part 1)

One of the most widely studied components to lower the bad cholesterol levels in the body is Red Yeast Rice a fermented rice that is consumed in many parts of Southeast Asia. However, it has also found its use as a powerful supplement to lower LDL levels and promote good cardiovascular health.

A study on 25 people showed how a regular consumption of red yeast rice for a period of 2 months, which lowered total cholesterol levels by 15% and bad cholesterol levels by 21%. Another 2 month long study on 79 people showed similar results.

To be more particular, the people involved consumed 600mg of red yeast rice twice a day, coinciding with their regular meals. Red yeast rice is established as a nutraceutical. It consists of a various compounds such as:

  • Unsaturated fatty acids
  • Polyketides
  • Monacolins

Monacolins in particular block the functionality of hydroxy-3-methyl-glutaryl-coenzyme, which constraints the synthesis of cholesterol. Red yeast rice has up to 13 monacolins. Out of these 13, monacolin K works pretty similarly to lovastatin, which is one of the best drugs to lower bad cholesterol.

(Part 2)

Another popular ingredient that has undergone extensive research in recent times is glucomannan. This is a water-soluble fiber which is derived from the roots of the elephant yam, an Asian plant. 14 different studies with varying doses and number of participants have showed that glucomannan lowered total cholesterol levels and bad cholesterol levels by 19mg/dL and 16mg/dL respectively.

The cholesterol lowering properties of glucomanna is attributed to its low energy density and its ability to increase the volumetric mass, which helps in shifting the energy of the other nutrients. This results in the feeling of fullness since all the water is absorbed and retracted in the intestines. As such, it decreases the total cholesterol  and LDL cholesterol  levels. The intestines also absorb lower cholesterol than before. The increased viscosity levels are the reason behind the lower rate of absorption. This also reduces appetite.

(Part 3)

Finally, a superfood: garlic. It has been found that households that cook and consume garlic on a frequent basis develop lower risk of heart disease and cholesterol problems. In fact, a man belonging to a family with heart disease history, never had any heart problems due to his regular consumption of garlic in his diet.

The consumption of garlic in subjects following a high-cholesterol diet showed that the LDL levels drastically reduced due to the lowering of the triglyceride of cholesterol. Basically, the decrease in the oxidation of LDL and the significant increase in HDL tremendously improved cardiovascular health. Studies show a 50% reduction in atherosclerosis in people with high LDL levels and the inhibition of the viscous synthesis of cholesterol within the bulk of the blood vessels.


Cholesterol is directly related to the good health of your heart. Doctors have noted that most cases of heart diseases are heart attacks in their patients are due to high levels of bad cholesterol and low levels of good cholesterol in their blood vessels. As such, cholesterol lowering supplements tend to become general health supplements that help to protect your body against cardiovascular issues. The cholesterol lowering supplements stated in this article are the best products for good heart health management and good HDL/LDL ratio. Try these products. Your heart will thank you. 🙂

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